Clinical Pharmacology and Therapeutics

Preface vi

Contributors vii

Part 1 Principles of clinical pharmacology

1 Pharmacodynamics and pharmacokinetics 3

2 Clinical trials and drug development 29

3 Pharmacoeconomics: the economic evaluation of new drugs 35

4 Practical prescribing 42

Part 2 Aspects of prescribing

5 Gastrointestinal system 51

6 Cardiovascular system: Management of coronary artery disease and its complications 63

7 Respiratory system 102

8 Nervous system 113

9 Infection 142

10 Drugs and endocrine disease 175

11 Genitourinary system 196

12 Malignant disease 211

13 Drugs and the blood 221

14 Musculoskeletal system 236

15 Immunopharmacology 242

16 Travel medicine 255

17 Analgesia and anaesthesia 266

18 Poisoning and drug overdose 281

Index 295

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