Pancreas

Contributors Preface Abbreviations About the Companion Website Section 1 Anatomy of the Pancreas 1 Development of the Pancreas and Related Structures Brian Lewis and Junhao Mao 2 Anatomy, Histology, and Fine Structure of the Pancreas Daniel S. Longnecker, Fred Gorelick, and Elizabeth D. Thompson 3 Congenital and Inherited Anomalies of the Pancreas Martin Zenker and Markus M. Lerch Section 2 Physiology and Pathophysiology of Pancreatic Functions 4 Physiology of Acinar Cell Secretion Ole H. Petersen 5 Physiology of Duct Cell Secretion Mei Zeng, Laura Vachel, and Shmuel Muallem 6 Pathophysiology of Experimental Pancreatitis Vikas Dudeja, Rajinder Dawra, and Ashok K. Saluja 7 Physiology and Pathophysiology of Function of Sphincter of Oddi Savio George Barreto and James Toouli 8 Neurohormonal and Hormonal Control of Pancreatic Secretion Chung Owyang 9 Regulation of Pancreatic Protein Synthesis and Growth Maria Dolors Sans and John A. Williams 10 Fibrogenesis in the Pancreas: The Role of Stellate Cells Minoti V. Apte, Romano C. Pirola, and Jeremy S. Wilson 11 Fibrogenesis of the Pancreas: The Role of Macrophages Aida Habtezion 12 Insulo Acinar Relationship Keiko Shiratori and Kyoko Shimizu Section 3 Acute Pancreatitis 13 Epidemiology and Etiology of Alcohol ]Induced Pancreatitis Jeremy S. Wilson, Romano C. Pirola, and Minoti V. Apte 14 Epidemiology and Etiology of Acute Biliary Pancreatitis Michael G.T. Raraty, Andrea Sheel, and John P. Neoptolemos 15 Genetic Factors in Acute Pancreatitis Zachary Zator and Georgios I. Papachristou 16 The Role of the Intestine and Mesenteric Lymph in the Development of Systemic Inflammation and MODS in Severe Acute Pancreatitis Alistair B.J. Escott, Anthony R.J. Phillips, and John A. Windsor 17 The Role of Neurogenic Inflammation in Pancreatitis Jami L. Saloman, Kathryn M. Albers, and Brian M. Davis 18 Molecular, Biochemical, and Metabolic Abnormalities in Acute Pancreatitis Julia Mayerle, Frank Ulrich Weiss, Walter Halangk, and Markus M. Lerch 19 Histopathology of Acute Pancreatitis Gunter Kloppel 20 Clinical Classification Systems of Acute Pancreatitis John A. Windsor and Max S. Petrov 21 Clinical Assessment and Biochemical Markers to Objectify Severity and Prognosis Bettina M. Rau and Guido Alsfasser 22 Acute Pancreatitis Associated With Congenital Anomalies Christopher R. Schlieve, Andrew L. Warshaw, and Tracy C. Grikscheit 23 Acute Pancreatitis in Children Mark E. Lowe and Veronique D. Morinville 24 Acute Pancreatitis Associated With Metabolic Disorders, Infectious Diseases, or Drugs Ali A. Aghdassi and Markus M. Lerch 25 Radiologic Diagnosis and Staging of Severe Acute Pancreatitis Yoshihisa Tsuji Clinical Course and Medical Treatment of Acute Pancreatitis 26 Conservative Therapy of Acute Pancreatitis: Volume Substitution and Enteral and Parenteral Nutrition Timothy B. Gardner 27 ICU Treatment of Severe Acute Pancreatitis Scott R. Gunn and David C. Whitcomb 28 Use of Antibiotics in Severe Acute Pancreatitis: Indications and Limitations Rainer Isenmann and Mathias Wittau Interventional and Surgical Management of Acute Pancreatitis 29 Indications for Interventional and Surgical Treatment of Necrotizing Pancreatitis Thomas E. Clancy 30 Management of Infected Pancreatic Necroses: An Endoscopic Approach Eduardo Rodrigues ]Pinto and Todd H. Baron 31 Minimally Invasive Debridement and Lavage of Necrotizing Pancreatitis Rebecca Saunders, Michael G.T. Raraty, Chris Halloran, and John P. Neoptolemos 32 Open Surgical Debridement in Necrotizing Pancreatitis Lutz Schneider and Markus W. Buchler 33 Endoscopic Treatment of Biliary Acute Pancreatitis Ichiro Yasuda, Shinpei Doi, and Masatoshi Mabuchi 34 Strategies for the Treatment of Pancreatic Pseudocysts and Walled ]Off Necrosis After Acute Pancreatitis: Interventional Endoscopic Approaches Georg Beyer, Julia Mayerle, and Markus M. Lerch 35 Strategies for the Treatment of Pancreatic Pseudocysts and Walled ]Off Necrosis After Acute Pancreatitis: Surgical Treatment Naohiro Sata, Masaru Koizumi, and Alan K. Lefor 36 Management of Fluid Collection in Acute Pancreatitis Felix Lammerhirt, Frank Ulrich Weiss, and Markus M. Lerch 37 Management of Pancreatic Fistula in Acute Pancreatitis Jorg Kaiser, Thilo Hackert, and Markus W. Buchler Long-Term Outcome After Treatment of Acute Pancreatitis 38 Long ]Term Outcome After Acute Pancreatitis Christin Tjaden and Thilo Hackert Section 4 Chronic Pancreatitis 39 Molecular Understanding of Chronic Pancreatitis John F. Eisses and Sohail Z. Husain 40 Epidemiology and Pathophysiology of Alcoholic Chronic Pancreatitis Atsushi Masamune and Tooru Shimosegawa 41 Pain Mechanisms in Chronic Pancreatitis Pierluigi di Sebastiano, Tommaso Grottola, and Francesco F. di Mola 42 Natural History of Recurrent Acute and Chronic Pancreatitis Rohit Das and Dhiraj Yadav 43 Chronic Pancreatitis with Inflammatory Mass of the Pancreatic Head Ulrich F. Wellner and Tobias Keck 44 Early Chronic Pancreatitis Tetsuhide Ito, Masayuki Hijioka, and Tooru Shimosegawa 45 Hereditary Chronic Pancreatitis: Molecular Pattern, Clinical Consequences, and Management Principles Celeste Shelton and David C. Whitcomb 46 Epidemiology and Pathophysiology of Tropical Chronic Pancreatitis Shailesh V. Shrikhande and Savio George Barreto 47 Cystic Fibrosis (CFTR) ]Associated Pancreatic Disease Chee Y. Ooi and Aliye Uc 48 Clinical and Laboratory Diagnosis of Chronic Pancreatitis Julia Mayerle, Peter Simon, and Markus M. Lerch 49 Evidence of Contrast ]Enhanced CT and MRI/MRCP J. Enrique Dominguez ]Munoz, Roberto Garcia ]Figueiras, and Julio Iglesias ]Garcia 50 Chronic Pancreatitis: Risk Factors in Cancer Albert B. Lowenfels and Patrick Maisonneuve Conservative Treatment of Chronic Pancreatitis 51 Pain Management in Chronic Pancreatitis Kai Bachmann, Stephanie Plagemann, Yogesh Kumar Vashist, and Jakob R. Izbicki 52 Medical Treatment of Chronic Pancreatitis: Pancreatic Digestive Enzymes: Lipases, Proteases Mark E. Lowe 53 Nutritional Support of Chronic Pancreatitis Sinead N. Duggan and Stephen J. O Keefe 54 Medical Therapy for Chronic Pancreatitis: Antioxidants Chris E. Forsmark Strategies for Endoscopic and Surgical Treatment of Chronic Pancreatitis 55 Evidence of Endoscopic and Interventional Treatment of Chronic Pancreatitis and Pseudocysts Jorg Schirra, Markus M. Lerch, and Julia Mayerle 56 Indications and Goals of Surgical Treatment Ryan T. Groeschl and Michael B. Farnell 57 Pancreatic Duct Drainage Procedure Dirk Bausch and Tobias Keck 58 Duodenum ]Preserving Pancreatic Head Resection Hans G. Beger, Bertram Poch, Yang Yinmo, and Waldemar Uhl 59 Major Pancreatic Resection May C. Tee and Michael B. Farnell 60 Laparoscopic Surgery Vernissia Tam, Melissa E. Hogg, and Amer Zureikat Management of Diabetes and Long-Term Outcome of Chronic Pancreatitis 61 Chronic Pancreatitis: Long ]Term Outcome After Medical and Surgical Treatment Volker Asfalg, Norbert Huser, and Helmut Friess 62 Management of Pancreatic Diabetes Secondary to Chronic Pancreatitis Keiko Shiratori Section 5 Autoimmune Pancreatitis 63 Epidemiology of Autoimmune Pancreatitis Terumi Kamisawa and Tooru Shimosegawa 64 Pathogenesis of Autoimmune Pancreatitis Yoh Zen 65 Histology of Autoimmune Pancreatitis Rajib Gupta and Vikram Deshpande 66 Clinical Manifestation of Type 1 Autoimmune Pancreatitis Tooru Shimosegawa, Morihisa Hirota, and Atsushi Kanno 67 Clinical Manifestations of Type 2 Autoimmune Pancreatitis Emma L. Culver and George Webster 68 Laboratory Diagnosis of Autoimmune Pancreatitis J. ]Matthias Lohr, Pia Maier, and Stephan L. Haas 69 What is the Evidence Measuring Immune Markers Shigeyuki Kawa 70 Imaging Diagnosis of Autoimmune Pancreatitis Kazuichi Okazaki, Tsukasa Ikeura, Kazushige Uchida, and Makoto Takaoka 71 Medical Management of Autoimmune Pancreatitis Shounak Majumder and Suresh T. Chari Long-Term Outcome of Management of Autoimmune Pancreatitis 72 Long ]Term Outcome After Treatment of Autoimmune Pancreatitis Luca Frulloni and Nicolo de Pretis Section 6 Neoplastic Tumors of the Exocrine Tissue: Benign Cystic Neoplasms of the Pancreas 73 Epidemiology of Cystic Neoplasms of the Pancreas Saurabh Mukewar and Suresh T. Chari 74 Histologic Classification and Staging of Cystic Neoplasms Noriyoshi Fukushima and Giuseppe Zamboni 75 Molecular Mechanisms of Cystic Neoplasia Nickolas Papadopoulos and Ralph H. Hruban 76 Clinical Presentation of Cystic Neoplasms Susumu Hijioka, Kazuo Hara, Nobumasa Mizuno, Nozomi Okuno, and Kenji Yamao 77 Evaluation of Cystic Lesions Using EUS, MRI, and CT Anne Marie Lennon and Hiroyuki Maguchi 78 Cytologic Evaluation of Cystic Neoplasms Martha Bishop Pitman 79 Natural History of Cystic Neoplasms: IPMN, MCN, SCN, and SPN Anna ]Katharina Stadler, Thilo Hackert, Stefan Fritz, and Markus W. Buchler 80 Surveillance or Surgical Treatment in Asymptomatic Cystic Neoplasms Klaus Sahora and Carlos Fernandez ]del Castillo Local and Standard Surgical Treatment of Cystic Neoplasms 81 Duodenum ]Preserving Partial or Total Pancreatic Head Resection Hans G. Beger and Bertram Poch 82 Pancreatic Middle Segment Resection Calogero Iacono 83 The Indications For and Limitations of Tumor Enucleation Rosalie A. Carr, C. Max Schmidt, and Henry A. Pitt 84 Standard Surgical Management of IPMN, MCN, SPN, and SCN Lesions: Open Approach Miral Sadaria Grandhi, Barish H. Edil, and Richard D. Schulick 85 Surgical Treatment of Cystic Neoplasms: Laparoscopic Approach Richard A. Burkhart, Christopher L. Wolfgang, Markus W. Buchler, and Thilo Hackert 86 Management of Recurrence of Cystic Neoplasms Zhi Ven Fong, Christopher L. Wolfgang, and Keith D. Lillemoe Long-Term Outcome of Management of Cystic Neoplasms 87 Long ]Term Outcome After Observation and Surgical Treatment: What is the Evidence? Giovanni Marchegiani, Giuseppe Malleo, and Claudio Bassi Section 7 Neoplastic Tumors of Exocrine Tissue: Pancreatic Cancer 88 Epidemiology of Pancreatic Cancer Evelina Mocci and Alison P. Klein 89 Smoking, a Risk for Pancreatic Cancer: Experimental and Clinical Data Uwe A. Wittel, Bradley R. Hall, and Surinder K. Batra 90 Molecular Understanding of Development of Ductal Pancreatic Cancer Laura D. Wood and Ralph H. Hruban 91 Familial Pancreatic Cancer Alison P. Klein 92 Pathology of Exocrine Pancreatic Tumors Meredith E. Pittman and Ralph H. Hruban 93 Pancreatic Cancer: Precancerous Lesions Michael Noe, Lodewijk A.A. Brosens, and Johan Offerhaus 94 Clinical History and Risk Factors of Pancreatic Cancer Norbert Huser, Volker Asfalg, and Helmut Friess 95 Pancreatic Cancer Within the Uncinate Process: Radiologic and Clinical Characteristics Sebastian Hollander and Dieter Birk 96 The Role of EUS in the Diagnosis and Differential Diagnosis of Neoplastic Lesions Susumu Hijioka, Kazuo Hara, Nobumasa Mizuno, Nozomi Okuno, and Kenji Yamao 97 Radiologic Diagnosis of Pancreatic Cancer: CT, MRI Siva P. Raman and Elliot K. Fishman 98 Screening of Patients with Hereditary Pancreatic Cancer Michael Goggins 99 The Role of PET in Diagnosis of Pancreatic Cancer and Cancer Recurrence Norbert Huser, Volker Asfalg, Isabel Rauscher, and Helmut Friess 100 Tumor Markers in Pancreatic Malignancies Shin Hamada, Atsushi Masamune, and Tooru Shimosegawa 101 The Role of Laparoscopy and Peritoneal Cytology in the Management of Pancreatic Cancer Kyoichi Takaori and Shinji Uemoto 102 Clinical Assessment and Staging of Advanced Pancreatic Cancer Jennifer LaFemina, Ann K. Friedrich, and Giles F. Whalen Surgical Treatment of Pancreatic Cancer 103 Pancreatic Cancer: Indications for Resection Akimasa Nakao 104 Pancreaticoduodenectomy for Pancreatic Cancer, Short ] and Long ]Term Outcomes After Kausch Whipple and Pylorus ]Preserving Resection Jin He and John L. Cameron 105 Left Pancreatectomy for Body and Tail Cancer Georgios Gemenetzis and Christopher L. Wolfgang 106 Total Pancreatectomy: Indications and Limitations Seiko Hirono and Hiroki Yamaue 107 Laparoscopic and Robotic Resection for Pancreatic Cancer Deepa Magge, Herbert J. Zeh, and Melissa E. Hogg 108 Extended Radical Surgery for Pancreatic Cancer Thilo Hackert, Alexis Ulrich, and Markus W. Buchler 109 Palliative Pancreatoduodenectomy: Benefits and Limitations Christoph W. Michalski, Max Heckler, Mert Erkan, and Markus W. Buchler 110 Bypass Surgery for Advanced Pancreatic Cancer Jurgen Weitz, Thomas Pausch, Christoph W. Michalski, and Thilo Hackert Nonsurgical Palliation of Pancreatic Cancer 111 Endoscopic and Interventional Palliation of Pancreatic Cancer Takao Itoi Medical Treatment of Pancreatic Cancer 112 Neoadjuvant Treatment of Pancreatic Cancer: Downstaging Results Robert A. Wolff and Gauri Varadhachary 113 Adjuvant Chemotherapy in Pancreatic Cancer Robert P. Jones, Paula Ghaneh, and John P. Neoptolemos 114 Immunotherapy for Pancreatic Cancer Adrian G. Murphy, Elizabeth M. Jaffee, and Lei Zheng 115 Targeted Therapies for Pancreatic Cancer Vincent Bernard and Anirban Maitra 116 Palliative Chemotherapy for Advanced Pancreatic Cancer: Survival Benefit and Side Effects of Treatment Olusola O. Faluyi, Madhuchanda Chatterjee, and Daniel H. Palmer 117 Management of Pain in Pancreatic Cancer Michael Erdek, Indy Wilkinson, and Zackary E. Boomsaad 118 Role of Radio and Proton Beam Therapy for Pancreatic Cancer Amol K. Narang, Lauren M. Rosati, Michael D. Chuong, and Joseph M. Herman 119 Management of Cancer Recurrence Oliver Strobel and Markus W. Buchler Long-Term Outcome After Treatment of Pancreatic Cancer 120 Survival and Late Morbidity After Resection of Pancreatic Cancer Avinoam Nevler, Charles J. Yeo, and Jordan M. Winter Section 8 Neoplastic Tumors of the Endocrine Pancreas: Neuroendocrine Tumors of the Pancreas 121 Epidemiology and Classification of Neuroendocrine Tumors of the Pancreas J.J. Mukherjee, Kok ]Onn Lee, and Gregory Kaltsas 122 Pathology of Neuroendocrine Neoplasms Atsuko Kasajima and Hironobu Sasano 123 Molecular Genetics of Neuroendocrine Tumors Nickolas Papadopoulos and Ralph H. Hruban 124 Clinical Manifestation of Endocrine Tumors of the Pancreas Ken Kawabe and Tetsuhide Ito 125 Evidence of Hormonal, Laboratory, Biochemical, and Instrumental Diagnostics of Neuroendocrine Tumors of the Pancreas Kok ]Onn Lee, Gregory Kaltsas, and J.J. Mukherjee 126 Pancreatic Neuroendocrine Tumors in Multiple Neoplasia Syndromes Anja Rinke and Thomas Matthias Gress 127 Nonfunctioning Pancreatic Neuroendocrine Tumors: Diagnosis and Management Principles Takao Ohtsuka, Hideyo Kimura, and Masafumi Nakamura 128 Medical and Nucleotide Treatment of Neuroendocrine Tumors of the Pancreas Gregory Kaltsas, J.J. Mukherjee, and Kok ]Onn Lee 129 Interventional Radiology in the Treatment of Pancreatic Neuroendocrine Tumors Takao Ohtsuka, Hideyo Kimura, and Masafumi Nakamura Surgical Management of Endocrine Tumors of the Pancreas 130 Surgical Treatment of Endocrine Tumors: Enucleation Henning Dralle, Phuong Nguyen Thanh, and Andreas Machens 131 Local Treatment of Endocrine Tumors: Duodenum ]Preserving Partial or Total Pancreatic Head Resection and Pancreatic Middle ]Segment Resection Hans G. Beger and Wataru Kimura 132 Surgical Treatment of Endocrine Tumors: Major Oncologic Resection Henning Dralle, Phuong Nguyen Thanh, and Andreas Machens 133 Management of Insulinoma Keijiro Ueda, Linkaku Lee, and Tetsuhide Ito 134 Evidence of Medical and Surgical Treatment of Gastrinoma Ryuichiro Doi 135 Rare Neuroendocrine Tumors of the Pancreas: Management and Evidence of Surgical Treatment Ryuichiro Doi 136 Treatment of Neuroendocrine Tumors of the Pancreas and Biliary Tract Andrea Frilling, Ashley K. Clift, and Vito Cincinnati Long-Term Outcome After Treatment of Neuroendocrine Tumors of the Pancreas 137 Long ]Term Outcome After Treatment of Endocrine Tumors Andreas Machens and Henning Dralle Section 9 Periampullary Cancers and Tumors Other Than Pancreatic Cancer 138 Periampullary Cancer: Clinical Presentation and Diagnostic Strategies Amanda B. Cooper and Keith D. Lillemoe 139 Histology and Genetics of Cancer of the Papilla, Distal Common Bile Duct, and Duodenum Yue Xue, Michelle D. Reid, and N. Volkan Adsay 140 Adenoma and Adenocarcinoma of the Ampulla of Vater: Diagnosis and Management Omer Basar and William R. Brugge 141 Endoscopic Treatment of Adenomas of the Ampulla of Vater: Techniques, Results, Benefits, and Limitations Natsuyo Yamamoto, Hiroyuki Isayama, and Kazuhiko Koike 142 Surgical Treatment of Adenoma and Cancer of Papilla of Vater Hans G. Beger, Bertram Poch, and Bettina M. Rau 143 Surgical Treatment of Duodenal Cancer Fuyuhiko Motoi and Michiaki Unno 144 Surgical Treatment of Distal Cholangiocarcinoma Yukihiro Yokoyama, Tomoki Ebata, and Masato Nagino 145 Adjuvant and Palliative Chemotherapy of Periampullary Cancers Eyas Mohamed, Paula Ghaneh, and John P. Neoptolemos Long-Term Survival After Tumor Resection 146 Long ]Term Survival After Resection of Periampullary Cancer Masayuki Ohtsuka and Masaru Miyazaki Section 10 Transplantation of the Pancreas 147 Transplantation of Pancreatic Islets Bernhard J. Hering and Melena D. Bellin 148 Transplantation of the Pancreas Hans W. Sollinger and Dixon B. Kaufman Index

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• Gastroenterologia
• Cirurgia gastrointestinal e colorectal