Human Drug Targets
-15%
portes grátis
Human Drug Targets
A Compendium for Pharmaceutical Discovery
Zanders, Edward D.
John Wiley & Sons Inc
11/2015
456
Dura
Inglês
9781118849859
15 a 20 dias
The identification of drug targets in a given disease has been central to pharmaceutical research from the latter half of the 20th century right up to the modern genomics era.
Preface vii Chapter 1 Introduction 1 1.1 Magic bullets 1 1.2 Background to modern pharmacology 2 1.2.1 The receptor theory 3 1.2.2 Molecular pharmacology 4 1.2.3 Receptors, signals and enzymes 4 1.2.4 Recombinant DNA technology and target discovery 5 1.3 Drug and therapeutic targets in the biomedical literature 5 1.4 How many drug targets are there? 5 1.4.1 Systematic target discovery 6 1.5 Screening for active molecules 7 References 9 Chapter 2 Overview of the drug target compendium 11 2.1 Introductory comments 11 2.2 Selection of entries 12 2.2.1 Gene name and symbol 12 2.2.2 Drug/investigational compound name 12 2.2.3 Literature reference 13 2.2.4 Involvement in disease 14 2.3 Organization of entries 15 2.3.1 Cell surface and secreted proteins 16 2.3.2 Enzymes 16 2.3.3 Entries classified by subcellular location 17 2.3.4 Non ]coding RNAs 18 2.4 Summary of data entries 18 2.5 How to use this book 19 2.6 Final comments 21 References 21 Chapter 3 Cell surface and secreted proteins 23 3.1 G ]protein ]coupled receptors (GPCRs) 24 3.1.1 G ]protein ]coupled receptor (GPCR) ligands 39 3.2 Nuclear hormone receptors (NHRs) 43 3.3 Cytokines and receptors 45 3.4 Adhesion molecules 64 3.5 Host defence molecules 75 3.6 Transporters and channels 90 3.6.1 ATP ]binding cassette families and transporting ATPases 90 3.6.2 Solute carrier (SLC) families 96 3.6.3 Ligand ]gated ion channels 112 3.6.4 Voltage ]gated ion channels 116 3.6.5 Assorted transport and carrier proteins 128 Chapter 4 Enzymes: Part 1 135 4.1 Signalling enzymes 136 4.1.1 Protein kinases 136 4.1.2 Protein phosphatases 160 4.1.3 Cyclic nucleotides and phosphodiesterases 168 4.1.4 GTPase signalling proteins 170 4.1.5 Other signalling enzymes 176 4.2 Protein modification 179 4.2.1 Peptidases 179 4.2.1.1 Peptidase inhibitors 202 4.2.2 Glycosylation 208 4.2.3 Ubiquitylation and related modifications 218 4.2.4 Chromatin modification 230 4.2.5 Protein synthesis and folding 236 4.2.6 Other protein modifications 241 Chapter 5 Enzymes: Part 2 247 5.1 Lipids and related 248 5.2 Amino acids and related 267 5.3 Nucleotides and related 276 5.4 Carbohydrates and related 282 5.5 Vitamins, cofactors and related 293 5.6 DNA ]processing enzymes 296 5.7 RNA ]processing enzymes 304 5.8 Stress response and homeostasis 316 5.9 Miscellaneous enzymes 330 Chapter 6 Remaining annotated entries grouped by subcellular location 335 6.1 Cell surface and secreted proteins 335 6.2 Cytoskeleton 356 6.3 Cytoplasm to nucleus 364 6.4 Nucleus 375 6.5 Internal membranes and organelles 400 6.6 Cytoplasmic proteins 417 6.7 Subcellular location not annotated 424 Chapter 7 Non -Coding RNAs 437
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The identification of drug targets in a given disease has been central to pharmaceutical research from the latter half of the 20th century right up to the modern genomics era.
Preface vii Chapter 1 Introduction 1 1.1 Magic bullets 1 1.2 Background to modern pharmacology 2 1.2.1 The receptor theory 3 1.2.2 Molecular pharmacology 4 1.2.3 Receptors, signals and enzymes 4 1.2.4 Recombinant DNA technology and target discovery 5 1.3 Drug and therapeutic targets in the biomedical literature 5 1.4 How many drug targets are there? 5 1.4.1 Systematic target discovery 6 1.5 Screening for active molecules 7 References 9 Chapter 2 Overview of the drug target compendium 11 2.1 Introductory comments 11 2.2 Selection of entries 12 2.2.1 Gene name and symbol 12 2.2.2 Drug/investigational compound name 12 2.2.3 Literature reference 13 2.2.4 Involvement in disease 14 2.3 Organization of entries 15 2.3.1 Cell surface and secreted proteins 16 2.3.2 Enzymes 16 2.3.3 Entries classified by subcellular location 17 2.3.4 Non ]coding RNAs 18 2.4 Summary of data entries 18 2.5 How to use this book 19 2.6 Final comments 21 References 21 Chapter 3 Cell surface and secreted proteins 23 3.1 G ]protein ]coupled receptors (GPCRs) 24 3.1.1 G ]protein ]coupled receptor (GPCR) ligands 39 3.2 Nuclear hormone receptors (NHRs) 43 3.3 Cytokines and receptors 45 3.4 Adhesion molecules 64 3.5 Host defence molecules 75 3.6 Transporters and channels 90 3.6.1 ATP ]binding cassette families and transporting ATPases 90 3.6.2 Solute carrier (SLC) families 96 3.6.3 Ligand ]gated ion channels 112 3.6.4 Voltage ]gated ion channels 116 3.6.5 Assorted transport and carrier proteins 128 Chapter 4 Enzymes: Part 1 135 4.1 Signalling enzymes 136 4.1.1 Protein kinases 136 4.1.2 Protein phosphatases 160 4.1.3 Cyclic nucleotides and phosphodiesterases 168 4.1.4 GTPase signalling proteins 170 4.1.5 Other signalling enzymes 176 4.2 Protein modification 179 4.2.1 Peptidases 179 4.2.1.1 Peptidase inhibitors 202 4.2.2 Glycosylation 208 4.2.3 Ubiquitylation and related modifications 218 4.2.4 Chromatin modification 230 4.2.5 Protein synthesis and folding 236 4.2.6 Other protein modifications 241 Chapter 5 Enzymes: Part 2 247 5.1 Lipids and related 248 5.2 Amino acids and related 267 5.3 Nucleotides and related 276 5.4 Carbohydrates and related 282 5.5 Vitamins, cofactors and related 293 5.6 DNA ]processing enzymes 296 5.7 RNA ]processing enzymes 304 5.8 Stress response and homeostasis 316 5.9 Miscellaneous enzymes 330 Chapter 6 Remaining annotated entries grouped by subcellular location 335 6.1 Cell surface and secreted proteins 335 6.2 Cytoskeleton 356 6.3 Cytoplasm to nucleus 364 6.4 Nucleus 375 6.5 Internal membranes and organelles 400 6.6 Cytoplasmic proteins 417 6.7 Subcellular location not annotated 424 Chapter 7 Non -Coding RNAs 437
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