Handbook of Radiopharmaceuticals

Foreword

Preface

List of Contributors

About the Editors

Abbreviations

PART I: INTRODUCTION TO RADIOPHARMACEUTICALS

1. Targeted Diagnostic Radiopharmaceuticals: Design Options for Small Molecule Radiotracers

Michael R. Kilbourn

2. Concepts and Issues for Therapeutic Radiopharmaceuticals

Alexandra R. Sowa Dumond and Peter J. H. Scott

PART II: PRODUCTION OF RADIONUCLIDES

3. Production of Short Half-life PET Radionuclides

Michael R. Kilbourn, Melissa E. Rodnick and Mara Clark

4. Production of Radionuclides used in SPECT

Salma Jivan and Thomas J. Ruth

5. Production of Therapeutic Radionuclides

C. Shaun Loveless and Suzanne E. Lapi

PART III: SYNTHETIC METHODS FOR RADIOPHARMACEUTICALS

6. Synthesis of 13N- and 15O-labeled Radiopharmaceuticals

Krishna R. Pulagam, Vanessa Gomez-Vallejo, Fernando Lopez-Gallego, Luka Rejc and Jordi Llop

7. Radiochemistry with Carbon-11

Stephen Thompson, Steven Kealey, Selena M. Sephton and Franklin I. Aigbirhio

8. Fluorine-18 Radiochemistry

Allen F. Brooks, Katarina J. Makaravage, Jay Wright, Melanie S. Sanford and Peter J. H. Scott

9. Synthesis of 68Ga-labeled Radiopharmaceuticals

Benjamin P. Burke and Stephen J. Archibald?

10. Cu-Mediated Radiohalogenation of Organoboranes

Sean W. Reilly and Robert H. Mach

11. The radiochemistry of zirconium

Jason P. Holland

12. 99mTc Radiopharmaceutical Chemistry

Dionysia Papagiannopoulou

PART IV: PRACTICAL ASPECTS OF RADIOPHARMACEUTICAL PRODUCTION AND USE

13. Automated Synthesis Modules for PET Radiochemistry

Laura Bruton and Peter J. H. Scott

14. Automation of PET Radiopharmaceutical Quality Control

Arkadij Elizarov

15. Moving PET Drugs from the Lab to the Patient in USA

David W. Dick

16. Moving from the Lab to the Patient in Asia

Dae Yoon Chi

17. Moving a radiotracer form bench to bedside in Europe

Koen Vermeulen, Alfons Verbruggen, Guy Bormans and Frederik Cleeren

PART V: MAJOR APPLICATIONS OF RADIOPHARMACEUTICALS

18. Radiopharmaceuticals in Oncology

Jeroen A.C.M. Goos, Outi Keinaenen, Brian M. Zeglis and Jason S. Lewis

19. Neurological applications of Radiopharmaceuticals

Mehdi Djekidel and Nicolaas I. Bohnen

20. Cardiac Applications of Radiopharmaceuticals

John P. Bois and Robert J. Gropler

21. Radiopharmaceuticals in Pediatric Nuclear Medicine

Scott E. Snyder, Elizabeth R. Butch and Barry L. Shulkin

22. PET Imaging in Drug Discovery and Development

David J. Donnelly

INDEX

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• Química

radiopharmaceuticals, radiopharmaceutical reference; nuclear medicine; radiopharmaceutical sciences; molecular imaging; radiotherapy; neuroimaging; oncology imaging; cardiac imaging; radionuclides; SPECT; PET imaging; synthetic radiopharmaceuticals; Positron emission tomography; PET; Single photon emission computed tomography; SPECT; Nuclear medicine; Molecular Imaging; Radiotherapy; Radiopharmaceuticals; Radiochemistry; Neuroimaging; Oncology imaging